Sentence examples for by generating a mouse from inspiring English sources
By generating a mouse model that contained a mutation to the inhibitory phosphosite of Separase, we demonstrated that mice of both sexes are infertile.
By generating a mouse model that expresses a Separase S1121A point mutation, we previously demonstrated that inhibitory phosphorylation is critical for proper Separase regulation and genome stability during spermatogenesis, the gametogenesis process of males [28].
We therefore decided to promote normal adenosine metabolism in mouse glomerulus by generating a mouse line over-expressing ADA in podocytes.
The disease has been replicated by generating a mouse line expressing hAPP751 with the E693Q mutation under a murine Thy1.2 promoter.
We sought to elucidate the in vivo function of VEGF-NRP1 binding by generating a mouse line that selectively disrupts VEGF binding to NRP1.
We recently addressed the question of interchangeability of the two cadherins by generating a mouse model in which N-cad cDNA was introduced into the E-cad locus.
We tested the hypothesis that the overexpression of PKD1L2 found in ostes/ ostes mice causes neuromuscular dysfunction in these mice by generating a transgenic mouse overexpressing PKD1L2.
Furthermore, our finding opens the way to the construction of a mouse model for the assessment of trogocytosis in vivo by generating a transgenic mouse expressing a selectively transferred fluorescent protein under control of an appropriate promoter driving high levels of expression on professional APCs.
In this study, we tested the therapeutic potential of mIGF-1 in the skin by generating a transgenic mouse model in which mIGF-1 expression is driven by the keratin 14 promoter.
Although REST is a critical transcriptional regulator in neurogenesis, the lack of an obvious neuronal phenotype in the REST knockout model prompted the author "re-open" the case by generating a novel mouse model of REST deficiency.
The importance of decreased ERK pathway signaling was confirmed by generating a transgenic mouse with an inducible dominant negative MEK. Inducing the signaling defect selectively in T cells decreases Dnmt1, causing anti-DNA antibodies in mice without lupus genes, and higher anti-DNA antibody levels and an immune complex glomerulonephritis in mice with lupus genes.
