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Recent studies have suggested that Fu kinase activity also plays a very important role in germline stem cell fate control by generating a gradient BMP response.
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A stiffness gradient can be achieved by generating a chemical gradient or through localized phase transformation.
If clathrin localization were dependent on Ran signaling, this model would predict that Ran could act by generating a clathrin gradient around chromosomes, which in turn would promote microtubule nucleation or stabilization through recruitment of microtubule-binding proteins.
Fractures were created by generating a strong thermal gradient in a concrete block semi-submerged in liquid nitrogen.
Air bubbles flowing through a collapsed or fluid-filled airway might induce damage to the epithelium by generating a steep pressure gradient near the air bubble front [ 17].
As well known, it is possible to reduce the effect of molecular diffusion on the NMR signal collected in the magnetic field gradient by generating a series of spin echoes making the interpulse delay τ between π/2 and π pulses as short as possible.
Microfluidic technology can overcome these limitations by generating a long-term stable and controllable gradient of soluble factors that can be continuously monitored over time [ 12– 16].
The largest flood event recorded affected local groundwater flow orientation by generating an inversion of the hydraulic gradient for 16 h.
It is possible that the ENCDC population generates a gradient of GDNF by consuming or competing for GDNF.
Therefore, transport was initiated in this case by a proton concentration jump generating a pH gradient (pH 5.0 inside, pH 7.2 outside of the vesicle) in the presence of the different anions (30 mM Cl−, Br− or I−).
It is thought that chromosomes act as a spatial cue by locally generating a Ran-GTP gradient, which activates a plethora of spindle assembly factors in the vicinity of chromosomes (Clarke and Zhang 2008).
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