Sentence examples for by gene profiling using from inspiring English sources

Such a mechanism was elegantly explored by gene profiling using cell-culture system and the GR agonist Dexamethasone (Dex) [12].

Table 3 compares the expression of cell cycle-related genes by gene profiling using the 5'SAGE and 5'SOLiD methods.

This hypothesis is supported by the results of the luciferase assays showing that the transcriptional activity of c-MYC was significantly enhanced by Pim1 in a kinase-dependent manner, by gene expression profiling using a MYC-ER inducible system, and by the finding that changes in target gene expression were reversed by c-MYC inhibition when small hairpin RNA (shRNA) against c-MYC was introduced.

Although intrinsic subtypes of breast cancer were originally defined by gene expression profiling using DNA microarrays, most archival formalin-fixed paraffin-embedded samples are not amenable to cDNA microarray and subsequent studies revealed that subtypes can be accurately determined using immunohistochemical as a surrogate for molecular classification (Nielsen et al, 2004; Carey et al, 2006).

To determine the biological impact of GC structure on GR transcription, primary TM 86 and TM 93 cells were treated with DEX, FA, TA, or a vehicle control and total RNA was isolated 24 hr later followed by gene expression profiling using Agilent Whole Human Genome Microarrays.

This might be possible by performing gene expression profiling using QRT PCR or microarray analyses.

Moreover, very few informative transcripts have been identified by gene profiling [ 16] and the few studies that used this approach have relied on the differences in transcript levels measured at baseline versus two to three days after treatment onset [ 17].

In this study, we have used primary human macrophages and analysed the early host response induced by H5N1 and H1N1 viruses at 1, 3 and 6 h post-infection by employing comprehensive gene expression profiling using an Affymetrix microarray platform.

We then analyzed in vitro and in vivo tumorigenicity as well as the effect of Pim1 overexpression on c-MYC transcriptional activity by reporter assays and gene expression profiling using an inducible MYC-ER system.

In the important further study by Jones et al. on global gene expression profiling using microarrays and bioinformatics a molecular basis for differences in the developmental competence of oocytes matured in vitro in comparison with in vivo matured oocytes was elucidated [ 27].

Next, we used the Web-based on line tool IPA to identify the set of biological pathways that were regulated in our experiment by integrating gene expression profiles using gene ontology (GO).