Sentence examples for by gene dosage data from inspiring English sources

While the number of erythrocytes was not affected by gene dosage (data not shown), a significant positive gene dose-dependent effect was seen for white blood cells (F[2,83] = 14.785, p < 0.0001; Fig 5A) and platelets (F[2,87] = 14.695, p < 0.0001; Fig 5B).

Gene expression data were compared with genomic aberrations in 87 HER2+ tumors in order to identify genes affected by gene dosage.

An additional selective advantage of polyploidy might be that it allows to globally control gene expression by gene dosage regulation.

In order to statistically test whether gene expression was affected by gene dosage we applied an array CGH expression integration tool, ACE-it[6], in which the called array CGH and normalized log10 ratios for expression arrays were used as input data.

The bias by far exceeds what would be anticipated by gene dosage effects alone.

Thus, it is unclear if X chromosome gene-by-gene dosage responses are similar to autosomal gene-by-gene responses.

We have baseline values for gene-by-gene dosage compensation on autosomes, but not for the X chromosome.

At 13 weeks of age, the Lef1+/− females, but not males, also exhibited reduced cortical bone thickness (0.162 mm vs. 0.188 mm in wild-type females, p = 0.021), but the femoral length and mid-diaphyseal diameter were unaffected by the Lef1 gene dosage in either gender (data not shown).

Previous studies reported that CNVs can modify gene expression level and lead to consequent phenotypes by changing gene dosage (Zhang et al., 2009; Dong and Wang, 2015).

It is assumed that one or more genes on 17q contribute to neuroblastoma by a gene dosage effect.

> > We then asked whether SLC2A3 copy number affected GLUT3 protein levels by a gene dosage effect.