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Our analysis allows us to determine exactly which interactions predicted by gene circuit analysis remain ambiguous.
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However, the designed gene network by the proposed gene circuit design can robustly achieve the desired equilibrium point x e = [1.0000, 0.5899, 1.0557, 0.5739] and the molecular noise filtering is also improved by the proposed gene circuit design.
We extended the mathematical model of the plant clock gene circuit by incorporating the repression of multiple clock genes by TOC1, observed experimentally.
Therefore, the prescribed filtering ability γ is achieved by the proposed robust gene circuit design.
The MC4100z1 oscillations were among the most robust oscillations generated in a population of cells by synthetic gene circuits.
We model the gap gene network using the connectionist gene circuit formalism developed by Mjolsness et al. [ 9].
Generally, a solution of the circuit analysis is obtained by loop equations or nodal equations.
Two genes, LOC_Os06g39740 and LOC_Os06g39750, were annotated as "response to cold" by gene ontology (GO) analysis.
We assume that the gene circuit acts as a functional unit responding to an external input by producing output.
By using the best parameter solution from PEDI, we next analyzed regulatory mechanisms of this gene circuit.
PEDI decomposes a gene circuit model into individual rate equations.
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