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The long-term clinical effects should be evaluated by future controlled trials.
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Therefore, specific protocols should be designed and tested in combination with other therapies in future controlled trials in patients affected by PD.
Future controlled trials expended longer would also support the effectiveness and safety of CIN in patients with refractory headache.
Future controlled trials expended longer with larger sample size, should also support the effectiveness and safety of venlafaxine in patients suffering from chronic migraine.
Future controlled trials are required to confirm the efficacy of this nomogram.
For the future, controlled trials investigating the safety profile of antifibrinolytic therapy are needed.
Future controlled trials are needed to confirm the benefits of acupuncture.
This study suggests the need for future controlled trials of OT, possibly in combination with behavioral treatment programs.
The potential advantage of the DLS 3.7 regarding secondary screw perforation has to be confirmed by future randomized controlled trials.
It is recommended that these research gaps may be addressed by focussing in future randomised controlled trials on the identified reasons.
Therefore, the results should be corroborated by future clinical randomized controlled trials.
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