The oral delivery of DNA vaccines by Salmonella requires further optimisation if it is to be commercialised.
Default options of the plotting functions were chosen to allow the generation of high-quality plots, and in addition, the layer-based structure of ggplot objects allows for further optimisation by the addition of customisation layers.
This will enable accurate characterisation of the vaccine for commercial licensing and further optimisation by modification of the ratio of eukaryotic and prokaryotic expression to improve vaccine immunogenicity.
Further optimisation could be possible by unequal weighting, which is a topic of ongoing work.
Although the potency of our lead AF2 inhibitor, VPC-16230, is less than that of tamoxifen, one must note that this is an early-stage compound and that its activity can be enhanced by further lead optimisation efforts.
An exploratory further optimisation is presently being evaluated by EARL [ 46, 47].
Specific notes and pitfalls to be considered: An exploratory further optimisation is presently being evaluated by EARL [ 46, 47 ].
The extra cost induced by the dynamic model is here about 20% but further optimisation remains possible.
Better knowledge of the pathways of cell death, growth arrest and premature senescence induced by cryotherapy in combination with chemotherapy will lead to further optimisation of these combination schedules to achieve a better clinical response.
