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The role of amygdala has been investigated also by functional studies that found different degree of amygdala activation in response to different emotional and perceptional tasks (table 2).
The analysis of differentially expressed genes also identified a set of genes specifically involved in the HSC niche and is complemented by functional studies that confirm the findings.
Indeed, genome-wide profiling integrated by functional studies that involve overexpression and downregulation of miRNAs represents the current approach that is most likely to yield advances in the new field of noncoding RNA research.
First, they demonstrate that combination genome-wide profiling followed by functional studies that involve over-expression and downregulation of miRNAs represent the approach that is most likely to yield advances in the field of noncoding RNA research.
This review summarizes the results obtained by functional studies that have addressed the roles and mechanisms of action of growth factors and cytokines in liver regeneration after acute injury to this organ.
While these observations need to be supplemented by functional studies that confirm the tentative identifications, they do raise a question that needs to be fully explored: did the adaptive immune response evolve earlier than presently thought?
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Although not included in the design or the scope of this study, direct control of target gene expression exerted by miRNAs may be established through functional studies that evaluate correlations with mRNA and protein levels [ 35, 36].
By this, they confirm and extend previous functional studies that provided support for a crucial role of the hippocampus in episodic memory by linking structural, instead of functional, correlates to episodic memory performance.
We herewith present a predictive study supported by biochemical and functional studies that successfully assigns an unexpected target (synapsin I) to a series of therapeutically important bioactive ligands (serine/threonine protein kinase inhibitors).
This two aspects resulted to be strictly linked by functional studies demonstrating that -35C allele leads to higher HLA-C cell surface expression and that AIDS and viremia progress slower in individuals with high-expressing HLA-C alleles compared to individuals with low HLA-C expressing alleles (-35T) [ 27, 65].
Further, structure-guided mutagenesis, followed by functional studies, demonstrated that N-terminal negatively charged residues, Asp4, Glu15 and Glu26, and C-terminal positively charged residues, K161, K162 and K163, are involved in secretion of EvpC.
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