Sentence examples for by functional proteomics in from inspiring English sources

Furthermore, in dilated cardiomyopathy (DCM) patients, increased expression of regulatory proteins of the UPS was demonstrated by functional proteomics in heart tissue specimens.

In an attempt to identify possible molecular targets involved in mutation reactivation of p53 by PRIMA-1, we used a functional proteomics approach in which cell lysates were co-immunoprecipitated with DO-1 primary antibody directed against p53 after treatment with PRIMA-1 followed by protein partner identification with MALDI-TOF mass spectrometry.

Four of these enzymes (cathepsins B, F, L and K) have been identified in S2 cells by a functional proteomics screen [27].

Three of them were discovered independently by a functional proteomics approach on the basis of induced proteolysis in vivo (Kanemaki et al, 2003).

By using functional proteomics approach, we sought to identify molecular targets that are involved in the restoration of normal function to mutant p53.

However, the MGC clones cannot easily be employed directly in functional proteomics experiments because they are in many different vector backbones and contain 5' and 3' untranslated sequences.

In addition to these functional proteomics studies, structural proteomic studies are also done with expectations to allow for pinpoint drug design and therapeutic intervention.

This study was supported by grants from the Functional Proteomics Center of the 21st Century Frontier R&D Program funded by the Korean Ministry of Education, Science and Technology, Republic of Korea.

This chapter focuses on mass spectrometry and its application in functional proteomics.

The selective release of target proteins from solid support is a key step in functional proteomics.

The acceptance of the protein species concept is a basic prerequisite for meaningful quantitative analyses in functional proteomics.