Sentence examples for by functional polymorphisms in from inspiring English sources

If the fibrinolytic pathway is involved in ovarian cancer, the risk does not appear to be influenced by functional polymorphisms in the key genes.

In HNSCC, degree of p16 INK4A silencing is also modified by functional polymorphisms in methylene tetrahydrofolate reductase, an enzyme that regulates serum folate levels (Kraunz et al. 2006).

There is evidence that the level of activity of IL-6 and its receptor are regulated by functional polymorphisms in the corresponding genes [ 17].

Since SNPs in the vitamin D receptor (VDR) genes have been associated also with protection from HIV-1 infection [ 124], it can be postulated that pro-inflammatory immune responses to viral infection or live viral vaccination are influenced by functional polymorphisms in the VDR gene.

Although intronic polymorphisms can affect gene expression by various mechanisms [ 47], there is no evidence that rs761142 is functional by itself; instead, the association observed in this study could be caused by other functional polymorphisms in LD with rs761142 responsible for lowering GCLC mRNA expression.

The objective of the present study was to investigate whether the associations of TDI and symptoms of the eyes and airways were modified by relevant functional polymorphisms in metabolizing enzymes and/or in proteins involved in airway inflammation.

This is supported by findings showing functional polymorphisms in Fas and Fasl genes between strains of mice with extremely different susceptibilities to certain tumors.

The concept that oxidant injury is a key early event in the pathogenesis of asthma is supported by evidence that functional polymorphisms in oxidant defence genes increase the risk of developing asthma in childhood (Salam et al., 2007; Castro-Giner et al., 2009).

Briefly, an enhanced production of ROS by blood neutrophils, monocytes, and eosinophils found in asthma can be explained by the effects of functional polymorphisms in the gene encoding p22 phox subunit (CYBA) of NADPH oxidase.

We tested this hypothesis by analysing the effect of functional polymorphisms in the genes coding for MMP9, MMP3 and annexin A5 on the risk of preeclampsia using a case-control design.

Potentially functional polymorphisms in EXO1 may alter cancer risks by influencing the repair activity of EXO1.