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We examined whether the relationship between coffee intake and incidence of CHD events is dependent on the metabolism of circulating catecholamines, as determined by functional polymorphism of the catechol-O-methyltransferase (COMT) gene.
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A functional polymorphism of the uPA gene has been described.
There is evidence that the level of activity of IL-6 and its receptor are regulated by functional polymorphisms in the corresponding genes [ 17].
In HNSCC, degree of p16 INK4A silencing is also modified by functional polymorphisms in methylene tetrahydrofolate reductase, an enzyme that regulates serum folate levels (Kraunz et al. 2006).
In a recent report by Li et al., two putatively functional polymorphisms of CASP8 were shown to contribute to melanoma susceptibility [36].
Previously, functional polymorphisms of Hp, coded by the co-dominant alleles Hp1 and Hp2, have been variously associated with several infectious diseases, including malaria susceptibility.
The response to amphetamine has also been found to be influenced by genetic factors; it depends on the functional polymorphisms of the Catechol O-methyltranserase (COMT) gene in a normal population of humans.
We hypothesized that common, functional polymorphisms of GNRH1 and GNRHR could influence breast cancer risk by modifying production of FSH/LH and steroid hormones.
Novel functional polymorphisms of the UGT2B17 and UGT2B15 genes have been recently characterized by in vitro assays but have not been evaluated in epidemiologic studies.
The functional polymorphisms of TLR2 have been reported [ 11].
Caspi et al. (2002) found the adverse effect of maltreatment on antisocial behaviors to be moderated by a functional polymorphism in the monoamine oxidase A (MAOA) gene.
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CEO of Professional Science Editing for Scientists @ prosciediting.com