Sentence examples for by functional knockdown of from inspiring English sources

Unexpectedly, we found that neurogenic differentiation was markedly perturbed by functional knockdown of MYC.

While LMP1 enhanced the number of invaded cells, functional knockdown of Fascin by two different small hairpin RNAs resulted in significant reduction of invaded, non-attached cells.

Vice versa, functional knockdown of IL-37 in primary human cells by siRNA increased the production of proinflammatory cytokines.

In conclusion, siRNA mediated functional knockdown of FOXA2 increased transcriptional activity of HNF6 and of genes targeted by this factor.

Thus, functional knockdown of FOXA2 recovered HNF6 activity.

It is of considerable importance that siRNA-mediated functional knockdown of FOXA2 resulted in transcriptional activation of HNF6 and of genes targeted by this factor.

Notably, functional knockdown of FOXA2 resulted in a significant 4-fold increase in HNF6 gene expression.

This result coincided with the functional knockdown of major histocompatibility complex I (MHC-I).

Knockdown of Atg5 in casp9−/− cells inhibited ER stress-induced autophagy as determined by a reduction in LC3-II levels compared to the vector only transduction (Fig. S3) verifying a functional knockdown.

(C ) Functional analysis by RNAi knockdown of the new pharyngeal progenitor marker SmedASXL_059179.

In order to expand our understanding of the relationship between the Basal-like subtype and impaired BRCA1-pathway function, we pursued functional studies by RNAi-mediated knockdown of two members of the pathway, RAD17 and RAD50, in order to emulate the genomic losses observed in tumors.