STPA handles safety as an emergent system property and specifically investigates risks generated by functional interaction between system components.
These links are mediated by the functional interactions between CYP2E1 and members of the alcohol dehydrogenase and glutathione s-transferase gene families (data not shown).
This hypothesis is supported through the physical associations between Ccr4-Not members and both hnRNPs and the NPC and also by the functional interactions between Not4 and many of the temperature sensitive NPC mutants (see Figure 4C) that have poly(A) RNA export defects at the nonpermissive temperature [19], [20], [21], [22].
By understanding the functional interactions between processes and molecules ongoing in living organisms, a much deeper understanding of the organismal response can be obtained.
As a way of ensuring this, in Europe the European Union Regulation 1035/2011 requires the Air Navigation Service Providers (ANSPs) responsible for the provision of ATM, to describe and model their systems by accounting for the functional interactions between the equipment, procedures and human resources of the ATM system.
As an alternative to these fork stalling and template switching (FoSTeS) models, Rad51 might also bypass the obstacle by recruiting translesion-synthesis polymerases able to incorporate dNTPs opposite DNA adducts, as supported by the physical and functional interactions between human Rad51 and Polη under conditions of replicative stress 35, 36 (Fig. 1, step 11).
These results suggest that HKIII is regulated by hypoxia and there are functional interactions between its two halves.
Based on our study, it seems reasonable to propose that the dissemination to the skeleton of breast cancer cells can be effectively counteracted by interfering with the molecular and functional interactions between the chemokine FKN and its only receptor CX3CR1.
Based on these considerations, we developed a novel metabolite pathway identification method that takes account of the above aspects by allowing the integrated analysis of functional interactions between metabolites in the global biological network and the character of the metabolomic profile.
Computational predictions such as those obtained by applying genome context methods usually measure functional interactions between proteins.
