Sentence examples for by functional expression of from inspiring English sources

For example, armed with this knowledge it would now be possible to narrow the search for a cyclohexanone receptor by functional expression of a subset of chemoreceptor transcripts expressed in the AWC neuron and/or by using the ODR-3 Gα as a probe to identify interacting GPCRs.

As the SP in BC is identified by functional expression of multidrug-resistant proteins, in particular BCRP, our findings may present a new rationale for the poor response of HER2-positive and hormone-resistant BC to conventional chemotherapeutics.

The identity of this clone was confirmed after identifying internal peptide sequences in the translated amino acid sequence of the isolated cDNA clone, as well as by functional expression of F6H in both prokaryotic and eukaryotic systems.

These regions form the binding site for acetylcholine and for certain agonists including neonicotinoids [ 49], where a number of key residues for toxin and neonicotinoid binding and selective toxicity in insect nAChR have been identified by functional expression of hybrid or chimeric receptors and by docking simulations (reviewed in [ 35, 50]).

This is the first report of an omega pore induced by functional expression of a calcium channel mutation in cultured cells, while previously studied muscle fibres may have been altered by secondary changes (Jurkat-Rott et al., 2009; Wu et al., 2012).

That indeed the specificity of lysis was governed by functional expression of the scFv anti-HER-2/neu)/ ζ chimeric gene wascFv anti-HER-2/neuted (i) by the inhibition of lyscFv anti-HER-2/neuargets following the addition of the anti-HER-2/neu MAb (range of % inhibition: 55–92) and (ii) by the inability of MD.45-mock effectors to lyse HER-2/neu− targets.

Our approach was to use it as an anchor for secretory proteins in cell culture and in vivo, as illustrated by the functional expression of TC-oleosin.

Our study demonstrated that the NMDA receptor antagonist MK-801 inhibited growth of HepG2, HuH-7, and HLF human hepatocellular carcinomas, and that the effects were induced by the functional expression of NMDA receptors in these cancer cells.

Subsequent identification of the TipE gene facilitated studies that demonstrated its NaV channel regulator activity by stimulating functional expression of Para in Xenopus oocytes, and established that TipE expression during pupal development rescued the paralysis phenotype in adult fruit flies [ 11].

Several of the apoptosis-controlling genes identified by functional expression cloning affect the sensitivity of breast cancer cells to apoptosis, including that caused by DNA-damaging agents.

Both proteins were characterized using mutant plants and by functional expression in yeast or functional complementation of yeast mutant strains.