Sentence examples for by functional analysis of from inspiring English sources

Secondly, the processed bam files were also employed for the identification of alternative splicing events using rMATS (replicate Multivariate Analysis of Transcript Splicing)27 followed by functional analysis of genes belonging to the enriched splice events.

This is achieved by functional analysis of histogram of each variable.

The roles of critical residues within the binding sites have been verified by site-directed mutagenesis followed by functional analysis of strains with variable HBGA-binding patterns.

All this is in line with the global patterning defects in the hindbrain of mib suggested earlier [28], [30], [41] and indicates that proper formation and position of ChP depend on Notch signalling as demonstrated by functional analysis of Notch signalling [35].

Additional studies should then be performed to determine whether identified changes are causal for the tumor formation and/or progression, for example by screening for additional mutations (e.g. deletions, missense mutations) in other tumor samples or by functional analysis of the identified mutants.

This has been confirmed by functional analysis of TRET1 in the anhydrobiotic insect, Polypedilum vanderplanki [ 34].

During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene.

We found that SP fraction cells are substantially enriched in tumour-initiating or cancer stem-like cells that can be defined by functional analysis and by expression of cancer stem cell and drug resistance genes.

Two approaches were used: (i) CD133 expression was functionally evaluated in HT29 after gene knockdown and (ii) SW480 underwent cell sorting into a CD133+ population and a CD133− population followed by comparative functional analysis of the two populations.

Initially the regulated expression of a viral recombinase in immune cells may have been positively selected by its ability to stimulate innate immunity to herpes virus infection rather than V(D J recombination Unlike the "RAG-transposon" hypothesis, the proposed model can be readily tested by comparative functional analysis of herpes virus replication and V(D J recombination.

This hypothesis is strongly supported by the functional analysis of the replicons in vitro, which revealed a major compensatory effect of the second T1087A mutation.