Syndrome is the overall "manifestation" of human body pathological and physiological changes expressed by four diagnostic methods' information.
Syndrome is the overall "manifestation" of human body pathological and physiological changes which can be expressed by four diagnostic methods' information; for example, tongue picture is not only the most important indicator of symptoms and disease patterns of human body, but also the external manifestation of overall body conditions [ 10].
Our preliminary studies have suggested that using data mining method, like complex network, as a medium study method can effectively achieve the integration of information collected by four diagnostic methods' information of patients with CHD and finally enable the recognition of disease patterns [ 11, 12].
Differentiation of syndromes implies that the patient's symptoms and signs collected by the four diagnostic methods (inspection, auscultation ant olfaction, inquiry, pulse-taking and palpation) are analyzed and summarized to identify the etiology, nature and location of a disease, thereby determining what syndrome the disease belongs to.
Although the genomics research status was not involved in this study, the characteristics, such as integrity, dynamics, temporality, spatiality and complexity shared by both TCM four diagnostic methods' information and the concept of "omics" were firmly grasped by this research.
We obtained four decision tree models of blood stasis syndrome diagnosis by extending tongue characterizations to 30 TCM four diagnostic methods' information of statistical significance and exploring with data mining methods of decision tree model.
Six attributes, including collaterals' color, cyanotic lips, collaterals' length, loss of appetite, cyanotic hands and fingernails, dark red lips, and gingival are selected by CHAID algorithm after screening 30 pieces of four diagnostic methods' information.
The 107 four diagnostic methods' information items could be classified into HPO by 6 kinds of methods, which had been described detailedly at the section of "Results HPO categorization results of 107 pieces of four diagnostic methods' information".
After a series of reasoning, we believe that 107 pieces of four diagnostic methods' information can be classified as the extended entry of characterization items in HPO, and based on the characteristics possessed by TCM four diagnostic methods' information, we managed to add them to HPO by six classification methods.
In a study comparing four diagnostic methods, C. suis were demonstrated in 42% of the samples by PCR and in 33% by culture.
Method for Classifying the 107 Four Diagnostic Methods' Information Items into HPO.
