Sentence examples for by four computational methods from inspiring English sources
The pathogenicity of each novel disease-segregating mutation was predicted by four computational methods: MutPred (http://mutpred.mutdb.org/), SNPs&Go (http://snps-and-go.biocomp.unibo.it/snps-and-go/), Mutation taster (http://www.mutationtaster.org/), and SIFT (http://sift.jcvi.org/).jcvi.org/
Calculated binding energies by two computational methods displayed that the fluorine replacement changed the binding affinity of drug.
The "Cancer" section summarizes the calculated results of driver genes by eight computational methods for a specific cancer type/dataset and provides three levels of biological interpretation for realization of the relationships between driver genes.
We did not include the low confident DDIs that were only predicted by one computational method, reducing the number of DDIs to 6689.
Four computational methods were used to predict the stability change of the structure caused by these mutations.
The mitochondrial localization of SK2 is further corroborated by positive predictions by the two computational methods TargetP 1.1 and Mitoprot II of a mitochondrial targeting sequence in human SK2 channels (accession number: AAP45946).
We downloaded all the driver genes inferred by the DriverDB resources and we found that all the five genes affected by missense RRAs in our uveal melanoma dataset were predicted as driver gene in at least one cancer type by one of the eight computational methods (Additional file 1: Table S3).
For the first time, the experimental study of polymeric drug release was accompanied by a hierarchical sequence of three computational methods.
Our off-target CNV calls were compared against the 1000 Genomes gold standard set of genotyped deletions that were created by combining the predictions of five computational methods to maximize confidence.
Using two computational methods, candidates for Giardia U1, U2, U4 and U6 snRNAs were identified in this study and shown by RT-PCR to be expressed.
The two computational methods are applied to the crystal structures of known systems.
