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Thus, treatments are selected by forward simulation with a clinically specified desired risk of light hypoglycaemia (5% BG < 4.4 mmol/L) due to these possible future variations.
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We generated synthetic alignments by forward simulation of the evolutionary process with the simgenome program [36] followed by re-alignment with PECAN [44].
The present method was validated using finite element method (FEM) by forward simulation.
Results from forward simulation with obtained aggregation kernels were in agreement with transient aggregate size data from experiments.
We determine the initial condition by finding the time where the sea surface profile from the adjoint simulation best matches the sea surface profile of the equivalent forward simulation with zero gravity (as in the top of Fig. 10).
For example, previous work by Kim and Stephan (1999) analyzed a single locus under a constant selection coefficient, using a diffusion approximation, and two recent simulation studies employed forward simulations with loci parameterized by constant selection coefficients to obtain power estimates (Baldwin-Brown et al. 2014; Kofler and Schlotterer 2014).
According to the demographic models from BSPs, we employed SFS_CODE26 to conduct forward simulations with the effect of purifying selection.
According to the demographic models from BSPs (Check Figure S5 for details), we employed SFS_CODE to conduct forward simulations with the effect of purifying selection26.
We do this using forward simulations with finite sites, allowing positive selection to occur at different times.
Starting with founder individuals for which we have full-genome haplotypes, we run neutral forward simulations with forqs to recombine the haplotypes and expand the population size.
The number of individuals of each genotype migrating to and from each population in a given generation is determined by the forward simulation and is therefore treated as a constant during the backward simulation.
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