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The patient was treated with one dose of intrathecal methotrexate, followed by five courses of high dose intravenous methotrexate with leucovorin rescue over the ensuing weeks.
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That was followed by two courses of radiation therapy at the Royal Marsden Hospital, Britain's leading cancer treatment center.
Two courses of bendamustine were used for debulking in patients with a high tumor load, followed by six courses of induction therapy with ibrutinib and GA101, followed by an MRD-triggered maintenance phase.
Before SCT or further chemotherapy, all patients received an intensive consolidation course with intermediate-dose cytarabine and mitoxantrone (HAM), followed by two courses of high-dose methotrexate and L-asparaginase (Figure 1).
This study consists of two parts: Study 1 targets the two periods (1994 1998 and 1999 2012) covered by two Courses of Studies (CoS), or sets of legally-binding curriculum guidelines, while Study 2 targets 2013 to the present.
Surgery is followed by six courses of chemotherapy consisting of Paclitaxel and Carboplatin.
The toxicity produced by two courses of methotrexate separated by different intervals has been studied in matched groups of rats.
Those patients underwent thoracotomy with extended lymph node dissection (ND3α) via median sternotomy [ 10], followed by two courses of chemotherapy.
The Topo/NB protocol consisted of two courses of topotecan/cyclophosphamide followed by two courses of ifosfamide/carboplatin/etoposide (ICE) and a later course of cyclophosphamide/doxorubicin/vincristine.
One hundred and thirty-six women were randomly allocated, to one of three treatment regimens: DTX 100 plus FEC 75, alternated for eight courses (ALT); four courses of DTX 100 followed by four courses of FEC 75 (SEQ T); or four courses of FEC 75 followed by four courses of DTX 100 (SEQ F).
Arm B: Epirubicin (single agent) 120 mg m−2 (bolus i.v). on day 1 every 3 weeks for four courses, followed by four courses of Paclitaxel (single agent) 250 mg m−2 on day 1 every 3 weeks (E → P).
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