The mean deactivation time constant (tau) was determined by fitting the current at the applied test potentials with a single exponential.
the time constants of inactivation were obtained by fitting the current traces to a sum of two exponential functions.
Erev was calculated by fitting the current from 0 mV to 60 mV to a linear equation, and determining the potential at zero current.
(C ) Inactivation rate (τinact) -voltage relationship was measured by fitting the current decay to a single exponential equation for NsvBa (Black), NaChBac (gray) and NavBp (purple).
When there are no parameter correlations, the number of linearly independent ZREs will be greater than NP and thus the true parameter point can be found by fitting the current data set.
Averaged inactivation time constants obtained from WT, Thr441Val and Thr442Val concatemers by fitting the current decay during 5 s (colored symbols, reproduced from Figure 6E ) or 20 s (empty symbols) depolarizations to +20 mV with a single exponential.
The results obtained by fitting the depolarization currents to the general kinetic order model are consistent with the existence of a space charge polarization mechanism with a distribution of trapping depths, which can be qualitatively described.
The permeability of the nicotinic channel (nAChR) at the ganglionic synapse has been examined, in the intact rat superior cervical ganglion in vitro, by fitting the Goldman current equation to the synaptic current (EPSC) I V relationship.
The hole mobility was determined by fitting the dark current to the model of a single-carrier SCLC, defined as J=9 ερ ερ μh V/8 d, where J is the current density, ε0 is the permittivity of free space, εr is the material relative permittivity, V is the effective voltage, and d is the thickness of the active layer, respectively.
The inactivation time constants were obtained by fitting the raw data current tracings from Knock et al., [51] and the simulated time tracings showed dynamics similar to the experimental time tracings (Figure 7C).
