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Half-lives are derived by fitting kinetic models to chemical residues plotted against time.
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Instead, we determined them by fitting the kinetic model to the HPLC data.
Our estimate of the rate of VEGF165 cleavage by plasmin at 37°C (kp = 631 M−1s−1) was derived by directly fitting kinetic data from Keyt et al. [6] to a one-step cleavage model (described in Supplement S1, section S1; Fig. S1A).
Determination of the [18F]FCho-to-[18F]FBet [18F]FCho-to-[18F]FBet [18F]FCho-to-[18F]FBete fitting of both kinetic models indicated that corrections for [18F]FBet uptake aratios mandatory.
Global fitting to different kinetic models, along with respective R values, is shown in Figure S1 of the Supporting Information.
The data were fitted to several kinetic models using a non-linear least squares fitting computer programme.
To analyze the mechanism of drug release from the matrix-tablets, the dissolution data were fitted to various kinetic models, the release kinetic parameters and the fitting ability (correlation coefficient, r) are listed in Table 4.
The fitting results using both kinetic models are summarized in Table 1.
The fitting results for the different kinetic models to the Si dissolution rates at different reaction times are listed in Table 2.
This is followed by the kinetic model suggested.
These results were described by a kinetic model [22], [28].
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