It is reported that the dynamic alterations of chromatin looping can either activate or suppress gene expression by facilitating the interactions between enhancers or silencers and their target genes.
Tmub1/HOPS and GABARAP/ubiquilin-2 increase the surface expression of receptors by facilitating the trafficking of the receptors to the cell surface [11], while Plic-1/ubiquilin-1 increases the surface expression of receptors by increasing the stability of the receptors in the intracellular compartment [9].
The availability of Gene Ontology [ 33] has had such benefits in the gene-expression microarray field, by facilitating the summarization of signals from thousands of genes into fewer, more readily interpretable categories using gene-family and pathway labels.
Consequently, LMO2 binding is likely to alter expression of E2A E2A targets by facilitating the displacement of SCL E2A from DNA.
The reduction in canonically spliced transcripts was commensurate with the reduction in cell surface ULBP1 protein, suggesting that RBM4 impacts cell surface expression of ULBP1 primarily by facilitating the correct splicing of the first two exons of ULBP1 transcripts.
Baseline levels of p-S727-STAT3 p-S727-STAT3 p-S727-STAT3creased in SLE patients compared to HCs. miRNAs are ubiquitous regulators of gene expression and function mainly by facilitating the degradation of mRNAs harboring partially complementary target sites [ 31].
Moreover, it would also be interesting to address the underlying mechanism by which KSR1 facilitates the expression of ISG15, STAT1, TAP1, MX1 and HLA-C in the case of genotoxic agents.
Phosphorylation of pRb by cyclin D facilitates the expression of cyclin E, a positive regulator of the G1 checkpoint (Lukas et al, 1995; Ohtsubo et al, 1995; Vidal and Koff, 2000).
During adipocyte differentiation, REV-ERBα acts downstream of the differentiation factor peroxisome proliferator receptor-γ (PPARγ) by facilitating gene expression of PPARγ target genes [ 103, 104].
Thus, by facilitating amplification and expression of the replication deficient Adeno-2B6/p35 Adeno-2B6/p35ther increases the CPA-induced and p35-enhanced bystander activity of CYP2B6.
