Sentence examples for by facilitating the binding from inspiring English sources

Interestingly HMGB1 was also shown to be involved in the p53 network by facilitating the binding of the tumor suppressor p53 to its cognate DNA [ 98].

In addition, PAK4 is needed for the efficient activation of survival pathways in response to TNFα by facilitating the binding of the scaffold protein TRADD to the activated TNFα receptor partly through a kinase-independent mechanism [ 149].

According to our in vitro data, even if horse serum contained IGF-1, AS-induced myotube hypertrophy did not entirely enhance the mTOR pathway by facilitating the binding of IGF-1 to its receptor.

Production of this 'yellow affinity substance' has been observed to precede the production of cellulases and also to be involved in the hydrolysis of cellulose by facilitating the binding of the cellulolytic enzyme complexes to cellulose [ 61, 64].

It is well known that core histones are acetylated immediately after translation in the cytoplasm and deacetylation allows their nuclear import by facilitating the binding of specific transporters to positively charged N-termini.

The transcription factor Dal81/Uga35, on the other hand, has a synergistic role on the induced expression of the SPS-regulated genes, by facilitating the binding of processed Stp1,2 to the promoters (Abdel-Sater et al., 2004; Boban & Ljungdahl, 2007).

In this sense, the binding of low-affinity nickel to the surface of NikR could help tune the affinity of NikR for the nik operon in response to the nickel concentration in the cell, either by facilitating the NikR−DNA binding interaction or by stabilizing the bound NikR−DNA complex.

It is also expressed at high levels on platelets (5000 20 000 copies per cell [6]) where, upon homophilic ligation or following stimulation with collagen or thrombin, it becomes tyrosine phosphorylated (Tyr and Tyr) by Src-family kinases [7 10] facilitating the binding of Src-homology 2 domain-containing signaling proteins [8,11].

This suggests that Oct4 DNA binding in some cases provides an anchor that, by physical interaction, facilitates the binding of other transcription factors.

The angle between the motor and neck domains that is taken by the prestroke conformation facilitates the binding of the ADP Pi-bound heADP Pi-boundin theadackward leaning orientotion actint the same tine impedes ithebackwardto actin in the forward leaning orientation.

Instead, it is better explained by the idea that attention facilitates the binding of the attended disk to the click and thus the point of perceptual simultaneity is attracted towards the attended stimulus.