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During adipocyte differentiation, REV-ERBα acts downstream of the differentiation factor peroxisome proliferator receptor-γ (PPARγ) by facilitating gene expression of PPARγ target genes [ 103, 104].
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However, modifier enzymes recruited by antisense RNAs, rather than facilitating gene expression, often make chromatine less prone to transcription [27], [43], [44].
The development of species-specific gene microarrays has greatly facilitated gene expression profiling in nonhuman primates.
This organisation into clusters may have been preserved to provide a mechanism for facilitating coordinate gene expression, by allowing adjacent clustered genes to share regulatory elements.
Genetic modification of pigs by SCNT facilitated gene targeting [ 5- 7], inducible transgene expression [ 8], and the first successful examples of zinc finger nuclease mediated targeted gene modifications [ 9, 10] to generate tailored large animal models and donor animals for xenotransplantation.
We demonstrated that WHSC1 is recruited to the ERα gene by the BET protein BRD3/4, and facilitates ERα gene expression.
It is also possible that the DNA repair mechanism and/or antioxidative defense were facilitated by differential gene expression, but the relation between these processes is not clear.
Thus, hypoxic regulation of JMJD1A acts as a signal amplifier to facilitate hypoxic gene expression, ultimately enhancing tumor growth.
This might facilitate coordinated gene expression during plant infection.
It not only represses gene expression [23], [24] but also facilitates gene transcription [25].
Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes.
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