Sentence examples for by facilitating binding of from inspiring English sources

Because AcH4 and H3K4me3 function to enhance gene transcription, in part, by facilitating binding of RNA polymerase II to promoters of regulated genes, we next assessed binding of RNA polymerase II to the TNF-α promoter at both 2 and 4 hrs post LPS treatment in sham and CLP macrophages.

Once activated, Epacs induce an enhanced activity of the monomeric G proteins, Rap1 and Rap2 by facilitating binding of GTP in place of GDP, leading to activation of phospholipase C  126.

It is a 58 kDa protein that is synthesized in the liver, and it potently enhances the sensitivity of monocytes and granulocytes to lipopolysaccharide (LPS) by facilitating binding of LPS to the CD14 cell membrane molecule [ 9, 10].

Previous studies have demonstrated PODXL to be a functional ligand of E- and L- selectins in pancreatic cancer suggesting that its expression may promote haemotogenic spread of metastases by facilitating binding of circulating tumour cells to selectin-expressing host cells [ 22].

In pancreatic cancer, PODXL has been demonstrated to be a functional ligand of E- and L-selectins, suggesting that its expression may promote haematogenic metastatic spread by facilitating binding of circulating tumour cells to selectin-expressing host cells (Dallas et al, 2012).

We conclude that the key role played by NL length in kinesin gating is twofold: (1) to enhance processivity by facilitating binding of the tethered head to the forward MT site at the binding gate, and (2) to increase velocity by accelerating rear-head release from the 2-HB state at the unbinding gate.

Hence, it can be speculated that increased chromatin accessibility mediated by NF-κB can facilitate binding of histone and DNA methylation complexes under certain conditions.

Posttranslational phosphorylation and acetylation of histone H3 lead to transcriptional activation by opening up chromatin structure to facilitate binding of the transcriptional apparatus [25].

By partially inducing these structural changes, paromomycin facilitates binding of near-cognate tRNAs.

The electrogenic interaction of the first Na+ ion with NaPi-IIa/b at a postulated Na1 site is accompanied by charge displacement, and Na1 occupancy subsequently facilitates binding of a second Na+ ion at Na2.

In MP, E1, and E3 cells, most GATA1 binding is at sites also bound by GATA2, consistent with the notion that GATA2 facilitates binding of GATA1.