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The Pish gene was mapped on chromosome 1 by an analysis of QTL due to its moderate resistance and isolated by extensive characterization of retrotransposon-tagged suppressive mutants (Araki et al. 2003; Takahashi et al. 2010).
Importantly, this technique was shown to be highly reliable as verified by extensive characterization of a combinatorial, site-directed mutant library in which all sequenced mutations mapped to the target sites.
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This notion was recently dispelled by the identification and extensive characterization of Mutator homologs in the first non-plant species [ 21- 24].
However, the comprehension of the role played by DMPK in DM1 is hampered by the absence of an extensive characterization of its intracellular functions.
We have recently carried out an extensive characterization of inclusion formation by avian reovirus muNS [11].
The extensive characterization of the extract by NMR and MS revealed that it contained triterpenic acids, triterpenic alcohols, and aldehydes.
The availability of WXS data obtained by The Cancer Genome Atlas (TCGA) repository provided an extensive characterization of the occurrence of mtDNA variants, also at low heteroplasmy levels, in COAD.
The extensive characterization of PGC morphology by video and electron microscopy has provided a framework for the positioning of the molecular machineries in the morpho-functional maps of various trafficking segments.
Another strength of the study was the extensive characterization of CVD risk by using multiple global CVD risk scores (FRS, TCSCORE, TC:HDL SCORE, Reynolds risk score, and QRISK2), along with comprehensive assessment of CVD risk factors, including HOMA and QUICKI.
Unless otherwise specified, we used the BAR-T line for most experiments because of the extensive characterization of this line done by our laboratory [5], [32], [34] [36].
Drosophila is a particularly attractive model because of previous extensive characterization of its satellite repeat content by methods other than sequencing.
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