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Nevertheless, immune escape is always endeavoured by coronaviruses by expression of mutant S proteins while nucleocapsid proteins have less mutations.
Finally, the miRNA expression profile in astrocyte-secreted exosomes is not perturbed by expression of mutant SOD1-G93A.
Animal models in which CREB function is enhanced, by overexpression of the protein, or reduced, by expression of mutant forms of the protein or through gene deletion experiments, are summarized in terms of identifying a role for CREB in behavioral responses in depression tests that were originally designed to evaluate antidepressant efficacy.
BERG, C. "Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphateglucuronosyltransferase Seppen J, Bosma PJ, Goldhoorn BG, Bakker CTM, Roy Chowdhury J, Roy Chowdhury N, Jansen PLM.
The striatal neuron damage caused by expression of mutant huntingtin induces the activation of microglia (Figure 7).
While it is clear that the UPS is an important cellular defence against toxic polyglutamine protein expression [34], it is less clear how its efficiency can be hindered by expression of mutant polyglutamine proteins.
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Knockdown of endogenous p53 increased MGMT promoter methylation in A549 cells, and transient expression of WT-p53 in p53 null H1299 cells diminished MGMT promoter methylation, whereas the MGMT promoter methylation status were unchanged by expression of mutant-p53.
It is now clear that DM is not caused by expression of a mutant protein.
CAG repeat diseases, caused by a toxic GOF, can be modeled in the fly by expression of the mutant protein.
As shown in Fig. 4B, the levels of TIF-positive cells were significantly increased by expression of the mutant hTERT.
This impairment was rescued by the expression of wild-type PI3Kγ but not by expression of the mutant PI3Kγ (Figure 2A).
More suggestions(16)
by expression of GEF-inactive
by expression of cre
by expression of specific
by misfolding of mutant
by quantification of mutant
by expression of oncogenic
by cloning of mutant
by transfection of mutant
by overexpression of mutant
by analysis of mutant
by expression of deleterious
by activation of mutant
by expression of cytoplasmic
by comparison of mutant
by generation of mutant
by expression of PGC1-α
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