Sentence examples for by expression microarray analysis from inspiring English sources
The data suggest that significant differential gene expression can be missed by expression microarray analysis but recaptured by integrating functionally relevant epigenetic modifications such as H3K9 acetylation.
To analyze the relation between the DNA methylation and the expression of genes, we plotted the methylation ratio calculated by MIAMI and the expression level calculated by expression microarray analysis for all genes examined (Fig. 7A).
By expression microarray analysis, 202 genes showed at least a 2-fold difference in expression with 108 being up- and 94 being down-regulated in strain R265 compared with strain R272.
This androgen-response signature was determined by expression microarray analysis, after stimulation of the different PC346 cell lines with the synthetic androgen R1881 or the antiandrogen hydroxyflutamide (Table S4).
The improvement of neuronal function by TFEB is supported by expression microarray analysis of hippocampal samples.
GCN4 was identified by expression microarray analysis as a positive regulator involved in such nutrient stresses [ 60].
Hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) was selected for use as a reference gene as its expression was shown to be stable across all experimental conditions by gene expression microarray analysis and by RT-qPCR analysis using a subset of representative samples.
Previously in an effort to understand FLCN function, we searched for differentially expressed genes in cells expressing mutant FLCN compared to wildtype FLCN by gene expression microarray analysis.
This analysis is particularly important for upstream regulators that are regulated at the protein level (e.g., by phosphorylation, or by ligand binding) and therefore would not be identified by gene expression microarray analysis.
In comparison, the genes Wnt3 and Wnt7a, which were found to be up-regulated by gene expression microarray analysis, were validated as up-regulated by real-time, RT-PCR and western blotting in SmoA1 +; Pten +/− medulloblastomas (Figure S1).
One approach to identifying candidate genes that are regulated epigenetically is to treat cancer cell lines with DNA methyltransferase inhibitors and/or histone deacetylase inhibitors, followed by an expression microarray analysis to identify genes that are upregulated by treatment.
