AAP exposure analysis was performed by collaborators from UC Berkeley and the Fresno field office.
On the other hand, if we used the time-dependent statin exposure analysis as proposed by Suissa (3), we obtained an HR of 1.74 (95% CI 1.30 2.31).
As described in the introductory remarks, previous data analyses often did not consider the uncertainty of the exposure analysis (e.g., by purely spatial or purely temporal analysis or linear assumptions).
However, sensitivity analysis by exposure definition showed that living less than 20 km from nuclear power plants was associated with a significant increase in the risk of thyroid cancer in well-designed studies (summary OR = 1.75; 95% CI 1.17 2.64).
The present analysis by exposure period and level has certain limitations.
However, the analysis by exposure level or period of exposure included those 1-BP female workers for whom no corresponding age-matched controls could be recruited.
One of the features of that work is an analysis by exposure window ("lag"), with exposure intervals of 1 to 5 years preceding death.
Supplemental Material, Appendix 2 (doi:10.1289/ehp.0900966.S1) lists the individual studies included in each overall and subgroup analysis by exposure time window and pesticide type.
In the analysis by exposure levels, the 27 exposed workers were classified into two groups: ≤2.64 ppm (n = 17) and ≥ 8.84 ppm (n = 7); data missing (n = 3).
To visualize the age- and sex-specific difference between exposed and nonexposed subjects, we stratified the regression analysis by exposure status (any SHS or no SHS) and plotted predicted CAC over age in both exposure groups.
