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The kind of study with which such knowledge could be obtained can only be conducted once the problem has been identified, which is the scientific purpose served by exploratory studies.
Future RCT in this area will have to be informed by exploratory studies.
Randomized controlled trials (RCT) are required to test relationships between physical activity and cognition in children, but these must be informed by exploratory studies.
Few implementation studies provide an underlying theoretical basis to explain how or why successful interventions work or have been preceded by exploratory studies to test the feasibility of or to refine an intervention.
Proof-of-principal for the value of osteoblast stimulation in the treatment of osteolytic breast cancer metastases was suggested by exploratory studies of bone parameters (reviewed [ 11] in the BOLERO-2 (Breast cancer trials of Oral Everolimus-2) trial (exemestane + the mTOR inhibitor everolimus) [ 12].
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Current clinical data on the cardiovascular effects of GLP-1R stimulation in humans have been provided by small, exploratory studies on intravenous administration of GLP-1 or through post hoc analyses of data obtained from phase III clinical trials of subcutaneously administered GLP-1R agonists.
The design of the questionnaire was informed by insights from the exploratory studies as well as findings from the literature.
Exploratory studies by Gursoy and colleagues [ 8] and García-Fructuoso and colleagues [ 9] uncovered an association between the Val-158-Met (rs4680) COMT transition and FM.
Subsequently, the proposed framework is being validated by an exploratory study undertaken at Parsons Brinckerhoff (USA) and BISOL Group (EU).
Heme oxygenase -1, encoded by Hmox1 gene, was shown to prevent the development of ECM but its role in human CM has not been addressed other than by an exploratory study in CM patients in Myanmar [20].
This trial was accompanied by an exploratory study of the pharmacokinetics of gemcitabine and of dFdCTP accumulation in PBMCs.
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