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This hypothesis has been supported by experiments demonstrating a correlation between AKT kinase activity and inhibition of p53 [ 272].
This scenario is supported by experiments demonstrating a dramatic decrease in the stability of the c-oligomers of Na+-translocating F-ATPases from I. tartaricus and P. modestum in the absence of Na+ [ 56].
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These findings were reproduced by transplantation of Fpr2−/− bone marrow into Ldlr−/− mice and further extended by in vitro experiments, demonstrating a lower inflammatory state in Fpr2−/− macrophages.
Integrating their findings with a cancer microarray database, these authors identified differentially expressed proteins that are targets of miR-128, a finding that was further supported by in vitro experiments demonstrating a role for miR-128 in prostate cancer invasion [ 39].
This hypothesis is further supported by other experiments demonstrating an up-regulation of SERCA1 in skeletal muscle after stimulation with insulin [ 1].
This theoretical finding is supported by experiments demonstrating that the energy from a single SNARE complex might not be sufficient to overcome the full fusion energy barrier [25], [30].
IGFBP7 has been proposed as a candidate tumour suppressor gene as suggested by experiments demonstrating suppression of tumourigenicity in murine lung, prostate and colorectal, breast and skin cancers xenograft models with rIGFBP7 [ 25, 26, 35, 62, 72].
The functional importance of this lower stem is supported by experiments demonstrating decreased frameshifting when the lower stem is destabilized by mutation or when a truncated construct containing only the upper stem is used.
NF90's functions have been coupled to those of NF45, suggested by experiments demonstrating that their expression is regulated coordinately [31].
2) Dual luciferase assay data should be supported by experiments demonstrating reporter mRNA integrity and abundance.
This view is, however, challenged by experiments demonstrating that parasites can perform better in well-fed hosts [ 5– 9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com