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However, the regulatory circuit the mutated MSTN forms with MYOD1 and IFRD1 cannot be deduced from GWAS data by existing statistical methods unless all 3-way epistatic interactions are exhaustively searched, and certainly not if the change in behaviour of MYOD1 and IFRD1 is solely dependent on the specific genetic change in MSTN.
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Many existing statistical methods for missing data require observations at individual levels.
Herein, we review some existing statistical methods used in GS.
However, many existing statistical methods neglect biological principles refreshed and updated from the latest scientific discoveries obtained by using new genomic technologies.
These effects are currently not adequately corrected using existing statistical methods.
Existing statistical methods for the detection of publication bias were applied on data from the included studies.
Existing statistical methods for adjusted indirect comparison and mixed treatment comparison are unbiased, but only if some assumptions are fulfilled.
Existing statistical-analysis methods are not designed for such discrimination because the null expectation of signal is set by sequencing technology considerations alone and not by a polymer model which incorporates the physical effects systematically.
To summarize, altmetrics should build on existing statistical and social science methods for developing reliable measures.
Moreover, it can be solved efficiently by existing methods.
The complexes derived by existing methods match few known complexes.
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