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The first characteristic is essential to establish mathematical models for actual metabolic systems consisting of hundreds to thousands of metabolites, whose concentrations cannot be measured practically by existing methods of measurement other than metabolomics.
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Considerable criticism has been raised about the following aspects of several proposed signatures: lack of robustness, various statistical and machine-learning related problems, low success rates for the cases that are hard to prognosticate by existing methods, and lack of biological meaning of gene lists, that were obtained without biological guidance.
All of them have at least one of the following three lines of evidence: (i) being predicted by existing methods, (ii) the existence of protein-protein interactions, and (iii) the co-annotation in the same MIPS functional categories.
Finally, gene exchanges between two nearest neighbors in the tree are ignored by all existing methods of HGT inference [ 28].
Some elementary test-cases that cannot be handled easily and properly by existing methods show the efficiency of the approach.
Importantly, since specificity of the allergen predictions by existing methods is questionable, a published list of twenty-five clinicandy and experimentally defined non-allergens was used to explore the possibility that the use of physical properties of the whole protein may supplement the utility of epitope based prediction methods for non-allergens.
When, however, we read about newspapers preparing for their digital destiny by challenging all existing methods of production and dissemination, it is hard to see how a ring-fenced Sunday staff sits alongside a gang of daily colleagues busy working new shift patterns.
The degree of leakage of air can be quantified by existing methods.
Then it becomes possible to observe the disruption of normal functions of many genes faster than by existing methods.
By applying geometric theory to 3-D reconstruction, our method is able to remove restrictions placed on the axes of curved surfaces by existing methods.
The experimental results show that our method outperforms others using one of features calculated by existing methods (DC, BC, CC, SC, EC, IC, NC, PeC, WDC and ION).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com