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Some of these noncoding transcripts such as miRNAs and lncRNAs have regulatory functions and likely contribute to the complexity of the organism by exerting additional control over protein expression.
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In humans, a major circulating inactive form of plasma oestrogen is oestrogen sulphate (E1S and E2S) that can be activated by intra-tumoural steroid sulphatases, thereby exerting additional in situ hormonal activity in oestrogen-dependent breast cancers (Chetrite et al, 2000).
These developments, combined with hopes for life unrestricted by racial segregation enforced by brutal violence, by lynchings especially, exerted additional pull-and-push forces that prompted hundreds of thousands to join in the migrations to the country's industrial centers.
Interferons exert additional inhibitory effects by regulating the extent to which lymphocytes and other cells express certain important molecules on their surface membranes.
However, disruption of cancer immortalization by inhibition of telomere extension would exert additional antineoplastic effects.
"The intensification of financial market turmoil is likely to exert additional restraint on spending, partly by further reducing the ability of households and businesses to obtain credit".
Moreover, the intensification of financial market turmoil is likely to exert additional restraint on spending, partly by further reducing the ability of households and businesses to obtain credit.
Overall, these climatic-induced changes in natural conditions exert additional pressure on the marginal environments of Eurasian Arctic, which are already stressed by human activities (Fondahl 1996; Crate 2006; Forbes et al. 2009).
Dimerization of GSTP1 subunits generates a catalytically active enzyme, whereas heterodimerization of GSTP1 with either JNK or 1-Cys Prx is a mechanism by which the GSTP1 enzyme exerts additional regulatory and antioxidative effects.
The modest effect of the inhibitory NRG-1 antibody could be explained by a modest binding ability of the antibody as well as ongoing proliferation promotion exerted by additional cytokines in the CAF-CM.
Inhibitors of VEGFR may not only restrain tumor growth by the inhibition of tumor angiogenesis, but exert additional inhibitory effects on tumor cells [ 74].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com