Sentence examples for by excessive activation of from inspiring English sources
Cytokine storm syndrome (CSS) is a life-threatening condition characterized by excessive activation of T cells and uncontrolled inflammation, mostly described in patients with familial hemophagocytic lymphohistiocytosis and certain systemic auto-inflammatory diseases, such as systemic juvenile idiopathic arthritis (sJIA).
IL-6 is known to induce neuronal death by excessive activation of NMDA receptors [53].
This is probably caused by excessive activation of the epidermal growth factor receptor (EGFR) [ 3].
The term excitotoxicity was coined more than 50 years ago, and refers to neuronal damage by excessive activation of glutamate ionotropic receptors.
Subsequently, many genetic studies reported that rs11221332 of ETS1 is associated with rheumatoid arthritis (RA) and celiac disease, both characterized by excessive activation of the immune system [ 10, 11].
In typical HUS, those reactions are initiated by binding of STx to the endothelial membrane-bound Gb3 receptor and subsequent activation of platelets and leukocytes, while in atypical HUS, those reactions are mediated by excessive activation of complement.
Our studies of a mouse model reveal that phospholipase Cγ1 (PLCγ1) is the dominant signaling effector by which excessive activation of TrkB promotes epilepsy.
rTM is a novel anticoagulant agent composed of the active, extracellular domain of thrombomodulin that regulates the imbalanced coagulation system by reducing excessive activation of thrombin [10].
It is possible that loss of FMRP and inactivation of α2A –AR may lead to epileptogenesis by allowing excessive activation of a common signaling cascade.
PE involves more than an imbalance in angiogenic factors, and is for instance characterized by an excessive activation of the maternal innate immune system, specifically neutrophils [65].
We administered 1 mg/kg dexamethasone intravenously to all our patients at admission, which might well have attenuated the production of NO by inhibiting excessive activation of inducible NOS.
