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Thus p53 levels and activity are fine-tuned by evolution to achieve the optimal balance between cancer-resistance and longevity.
The exhaustive compilation and analysis of all the instances in the PDB have partially revealed the molecular mechanisms used by evolution to achieve the dynamic nature and specificity required in this type of interaction.
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The single mutant F87A of cytochrome P-450 BM-3 from Bacillus megaterium was engineered by rational evolution to achieve improved hydroxylation activity for medium chain length substrates (C8 C10).
Dimerization has been used by this flavoenzyme in evolution to achieve maximal activity, a tighter interaction between the protein moiety and the coenzyme, and higher thermal stability.
While previous studies have employed rational design to improve Mxe GyrA production levels by reducing in vivo autocleavage or by reducing intein size, we instead employed directed evolution to achieve this goal.
What more may we expect human evolution to achieve, and when?
This is the way of evolution: to achieve a new function it makes use of something already to hand.
Genencor used directed evolution to achieve a fivefold improvement in the stain-removing ability of a bacterial enzyme in a year.
Eli Noam, the director of Columbia University's Institute for Tele-Information, calls the consolidation a natural evolution to achieve scale and diversify risk.
The integration of the perspectives of self-organization and evolution is straightforward to achieve by clearly distinguishing between the timescale of self-organization (within generations) and the timescale of evolution (between generations).
And after over 200,000 years of evolution, Homo sapiens, as a distinct species, may go extinct, not by a meteor or nuclear weapons, but by our desire to achieve perfection.
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