Sentence examples for by evaluating compounds in from inspiring English sources
Using a human 11β-HSD1 selectinhibitoritor as a starting point, we designed and synthesized a new class of derivatives of 1-arylsulfonyl piperidine-3-carboxamides. It was found that the large lipophilic group on the amino moiety may lead to cross-species potency towards human and mouse, allowing drug development by evaluating compounds in rodent model.
The predictions were then evaluated against an experimentally assessed "gold standard" generated by evaluating compound combination activity in vitro (M. Bansal et al., personal communication).
To test this hypothesis, we began by evaluating our compounds in two MCF7-derived TamR cell lines: TamR3 and TamR6.
Using this Locus Derepression assay, we queried 283,122 compounds by quantitative high-throughput screening evaluating compounds at multiple concentrations.
The involvement of the extracellular CaSR on observed stimulation of growth/proliferation in these cell lines was investigated by evaluating added compounds on CaSR mRNA and protein expression.
In addition, we were able to simultaneously evaluate compounds or extracts that inhibit bacterial growth and promote host survival by observing the turbidity of the liquid medium.
This study determined the bradycardia of 15 compounds by evaluating the change in heart beat rate (HBR) in zebrafish, hERG fluorescence polarization (hERG-FP), and ionic current change using a patch clamp (hERG-PC).
These methods will extend recent changes in toxicity testing, which were designed to respond to research on endocrine-disrupting compounds by evaluating how exposures in utero and during other windows of development set the stage for chronic diseases later in life.
This is an experimentally tractable question that could be addressed by evaluating natural variation in antifungal compound production and resistance or by creating microcosm communities with characterized phenotypes.
Here, we investigate defense strategies at the molecular level by evaluating the production of defense compounds (phenolic compounds in P. oceanica and Caulerpenyne (CYN) in C. taxifolia) and the influence of this production on growth over an annual growth cycle.
In this study, we have evaluated these compounds in vivo and further optimized their characteristics by shortening or lengthening the [18F]fluoroalkyl chains in their structures.
