Sentence examples for by escalating doses of from inspiring English sources
TGF-β1 induced collagen III mRNA was significantly reduced by escalating doses of juglone (Shen et al., manuscript submitted).
Each patient received 5000 U m−2 of MFECPHis (approximately 50 100 mg depending on individual weight and height) followed by escalating doses of prodrug ZD2767P after clearance of MFECPHis from blood.
Pasini et al (2005) conducted a phase I study in localised oesophageal cancer using induction weekly docetaxel, cisplatin and infusional 5-fluorouracil, followed by escalating doses of the same three agents concurrent with up to 50 Gy radiotherapy, then surgery.
Cohorts of three patients were treated with a fixed dose of 5 g m−2 treosulfan (Medac, UK), preceded by escalating doses of gemcitabine (Lilly Oncology, UK), commencing at a dose of 0.5 g.m and increasing in increments of 0.5 g m−2.
A phase 1 study of a new ribonucleotide reductase inhibitor, didox, was performed by administration of escalating doses of the drug by slow i.v. injection.
A vehicle control placebo followed by three single escalating doses of prGCD were administered via intravenous (IV) infusions.
To investigate the mechanism of antibacterial activity of this new chemotype, a resistant strain of S. aureus was generated by serially passaging the organism in escalating doses of the most active analogue.
In one trial, patients with relapsed CD19 B-cell lymphoma were treated with escalating doses of SAR3419 given by intravenous infusion once every 3 weeks for six cycles with the maximum tolerated dose of 160 mg/m.
Escalating doses of sedatives followed by oppressive hemodynamic and ventilatory side-effects sometimes provide an indication for therapeutic musculoskeletal paralysis to rapidly get control of life threatening agitation syndromes.
The German Testicular Cancer Group reported a 79% 2-year survival in 182 poor prognosis patients (IGCCCG criteria) who were treated with escalating doses of VIP followed by autologous stem cell support (Schmoll et al, 2003).
The rationale for HDCT is that escalating doses of HDCT may increase survival by capturing putatively remnant malignant cells and thus overcome cell resistance to standard chemotherapy [7].
