Sentence examples for by epigenetic modification of from inspiring English sources
Polycomb group (PcG) proteins are transcriptional repressors that help to maintain cellular identity during metazoan development by epigenetic modification of chromatin structure.
The silencing of a gene at the transcriptional level, that is, by preventing the transcriptional process, often by epigenetic modification of the locus to a less open conformation, disfavouring binding of RNA polymerase II.
To determine whether this hESC extract induced reprogramming was mediated by epigenetic modification of somatic cell chromatin, DNA methylation and histone acetylation levels were examined.
Such positional memory might be governed by epigenetic modification of homeobox containing or HOX-genes that have been shown to be important for patterning the primary and secondary axes [24], [25].
Some oncoviruses, including JC virus, may initiate carcinogenesis by epigenetic modification of different oncogenes.
Similarly, AtHAC1 was reported to regulate flowering time by epigenetic modification of factors upstream of FLC [ 6].
It not only acts as a critical component of PRC1 to contribute to the repression of gene expression by epigenetic modification on chromatin, but also functions as a SUMO E3 ligase to regulate tumorigenesis- or DNA-damage-associated proteins, such as heterogeneous nuclear ribonucleoprotein (hnRNP) K.
The mitochondrial dysfunction owing to CoQ10 deficiency induces a stable survival adaptation of somatic cells in patients at early or postnatal development by epigenetic modifications of chromatin.
