Sentence examples for by epigenetic changes that from inspiring English sources

These adverse outcomes are thought to be mediated by epigenetic changes that persist over time and affect long-term health conditions [ 14].

However, the growth inhibitory functions of TGF-β signaling are more commonly subverted by epigenetic changes that reduce receptor expression, prevent the nuclear localization of Smad2 and Smad3 proteins, or functionally inactivate them within a given gene regulatory complex [ 39].

In this phase, teams were asked to focus on specific gene changes common to many cancers as identified by The Cancer Genome Project (30) in order to estimate how the function of specific genes might be altered, not by specific gene mutations, but rather either by direct action or by epigenetic changes that might lead to the same functional ends.

28 This suggested that the famine experienced by the mothers caused epigenetic changes that were passed down to the next generation.

The progression from precursor intraepithelial lesions to cervical carcinomas is accompanied by additional genetic and epigenetic changes that have not been fully characterized.

As reviewed above, a large body of information exists on different genomic and epigenetic changes that are caused by smoking and other xenobiotic compounds.

It is possible that the better response in VHL-methylated cell lines might be because VHL-methyation is a marker for other critical epigenetic changes that are reversed by treatment with azacitidine.

In patients who received tamoxifen, inhibiting such regulation, or indeed the acquired genetic and epigenetic changes that are accumulated by residual breast cancer cells, could then positively select for a more aggressive cell phenotype, as previously suggested in experimental models [ 3, 13].

Multiple types of cancer are marked by drastic changes to TCA cycle enzymes, which result in characteristic metabolic and epigenetic changes that are correlated with disease transformation and progression.

She also believes that exposure to moderately high temperatures induces epigenetic changes that can help corals withstand very high temperatures.

Thus, by comparing the epigenetic state of myotubes to myoblasts we hope to discover patterns of epigenetic changes that are associated with genes that undergo coordinated epigenetic reprogramming during myogenesis [ 63].