The proteome complexity is increased by PTMs that play a role in protein location, protein-protein interactions and folding, enzymatic function and protein life-time.
b Putative enzymatic function and Enzyme Commission (EC) number are provided.
Additionally, hypothermia has the potential to impair hemostasis by slowing enzymatic function of the coagulation cascade, impairing thrombin generation, and further triggering DIC [ 8, 10– 10].
Even more compelling, however, is our finding that preeclampsia risk changed in a linear fashion when we ordered haplotypes by reported enzymatic function.
Rosen intended (M,R) to be interpreted very generally, as a representation of a whole metabolic system B produced from an entire set of nutrient sources A. Metabolic activity in B is catalysed by a set of enzymatic functions f and maintained by replacement functions Φ.
As R135C DHODH exhibited no apparent deficiency in stability or intermembrane space sorting, we next examined whether this mutation affected enzymatic function by measuring the DHO-dependent ubiquinone and cytochrome c reductase activities.
Tyrosine 783 on PLC-γ1 is phosphorylated by the Tec family kinase Itk and is essential for PLC-γ1 activation and enzymatic function [13], [24], [25].
Six sequences originally annotated (by GeneDB) as hypothetical proteins could be associated to an enzymatic function by AnEnΠ (more details in Additional file 2, Table S2).
One possible explanation is that TRIM3 enzymatic function is stimulated by activity and inactivated in the presence of chronic TTX.
The ETA server expands the ET suite for protein structure annotation (Mihalek et al., 2006; Morgan et al., 2006) by predicting enzymatic functions of protein structures without prior knowledge of functional sites or mechanisms.
