Sentence examples for by enhancing the affinity from inspiring English sources

In addition, substitution of the residues Pro211 and Ala212 or residue Glu221 which localized in the vicinity of a Ca2+ binding site of the enzyme by the corresponding residues in subtilisin S41 remarkably reduced the half-life of the enzyme at 70 °C, suggesting that the three residues contributed to the thermostability of the enzyme, probably by enhancing the affinity of enzyme to Ca2+.

FSS stimulation of osteoblasts also improved the cell adhesion by enhancing the affinity of intracellular integrins to extracellular matrix ligands as well as to biomaterial surfaces [20, 21].

eIF4G contributes to message selection by enhancing the affinity of these two factors for their substrates [2], [3], [4].

Further study has demonstrated that 14-3-3 14-3-3 14-3-3 GSK3 β-dependent phosphorylation of tau by enhancing the affinity of GSK3 β for tau [ 86, 87].

Furthermore, our group has shown that mutations in the 3′UTR of the CFTR gene may have a pathogenic effect by enhancing the affinity for the miR-509-3p miR-509-3p miR-509-3p

Interestingly, the activation of BimEL by caspases-3-dependent cleavage was described to induce a positive feedback amplification of the apoptotic signal by enhancing the affinity of BimEL to Bcl-2 [ 41].

We show that targeting can be augmented by use of contemporary antibody enhancement strategies such as the selective elimination of competing serum IgG using "receptor refocusing" enzymes and we envisage that further improvements are achievable by enhancing the affinities between the adaptor and its ligands.

Hence, PCNA ubiquitylation activates TLS by selectively enhancing the affinity of the damage-tolerant polymerases and thus recruiting them to their sites of action.

Thus the phosphate moiety within EBNA-1 NLS functions as a direct binding determinant for importin α5; phosphorylation of Ser385 within the NLS stimulates nuclear import by enhancing the binding affinity of EBNA-1 for the import adaptor importin α5.

PcTx1 modulates the gating properties of ASIC1 channels by enhancing the apparent affinity of these channels for protons, thereby promoting open and desensitized states of the channel (Escoubas et al., 2000, 2003; Chen et al., 2005; Salinas et al., 2006; Baconguis and Gouaux, 2012; Dawson et al., 2012), an allosteric mechanism related to that employed by tarantula toxins targeting Kv channels.

Moreover, the role of this residue, acts independently to the allostery imparted by Pdx2, which enhances the affinity for the substrate.