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Akt up-regulates GLUT1 by enhancing its expression at transcription level.
SHH-Receptor-binding reduces the concentration of free SHH but enhances the receptor concentration by enhancing its expression.
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The correlation between reduced repair of 8-OH-Gua and lack of OGG1 in HCC1937 cells would imply that adding the purified enzyme or enhancing its expression by transfection of the hOGG1 gene, would result in stimulation of the repair activity.
c-FOS gene is a protooncogene upregulated by numerous stimuli that enhance its expression and interaction with c-JUN to form heterodimers to regulate cell proliferation and differentiation [ 12].
The effects of PPAR agonists on iNOS expression are supported by our previous findings showing that PPARα agonists WY14643 and GW7647 regulate iNOS expression by enhancing its degradation [ 19].
HBV up-regulated miR-181a expression by enhancing its promoter activity.
Our study firstly showed that up-regulation of miR-181a in HBV-related HCC cell lines and HBV could induce miR-181a expression by enhancing its promoter activity.
Therefore, these studies suggest that suppressing P-gp expression by enhancing its degradation might be another effective strategy to modulate P-gp-mediated drug resistance.
These results demonstrate that Rep1 regulates human SNCA expression by enhancing its transcription in the adult nervous system and suggest that homozygosity for the expanded Rep1 allele may mimic locus multiplication, thereby elevating PD risk.
The oncogene MYC is one of the transcriptional targets of the WNT pathway, and it has been shown to enhance its own expression by promoting WNT signaling in tumors [ 71].
This argues against the hypothesis that p27Kip1 cooperates with Xpcl1 simply by enhancing the expression of its constituent miRNAs.
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