In the present study we demonstrate that microparticles of patients after successful cardiopulmonary resuscitation cause enhanced monocyte adhesion to the endothelium that is partly mediated by enhanced expression of the endothelial adhesion molecules ICAM-1 and VCAM-1.
This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density.
Considering these findings, we hypothesized that the THC-induced reduction in brain risperidone levels might be explained by enhanced expression of the ABC transporter P-gp.
Borderline subclinical rejection samples showed an intermediate amount of expression.These results demonstrate that histologic features of rejection are often accompanied by enhanced expression of pro-inflammatory gene transcripts, despite the absence of clinically overt graft dysfunction.
Ethanol challenge facilitated myocardial autophagy as evidenced by enhanced expression of Beclin, ATG7, and LC3B II, as well as mTOR dephosphorylation, which was alleviated by ALDH2.
Libraries of bacterial chromosomal fragments were screened using two separate systems that monitor: (i) elevated fluorescence conferred by enhanced expression of GPCR GFP fusions and (ii) increased binding of fluorescent ligand in cells producing more active receptor.
The greater potency of NMDA in kindled rats can probably be explained by enhanced expression of NMDA receptors in the presence of a receptor reserve.
In the present study, the apparently increased toxicity of sized (10 nm) ZnO-NPs (LC50, 0.62 g/l) may be attributed due to generation of more ROS as evident by enhanced expression of sod-1 gene.
For the latter two components, this is frequently accompanied by enhanced expression of their respective adhesion receptors, CD44 and αvβ3 integrin [6], [7].
One of the proposed mechanisms by which cancer stem cells resist chemotherapy is by enhanced expression of ATP-binding cassette (ABC) transport proteins, which are responsible for drug efflux.
In the present study we find an increase of single L-VDCC activity accompanied by enhanced expression of β2-subunits when these mice have entered the failing state ("Maladaptive State" ≥9 months of age).
