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This expression pattern suggests that formation of the placodes results from the migration of wnt-expressing cells along the milk line accompanied by enhanced expression in the cells that form the placode.
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The greater potency of NMDA in kindled rats can probably be explained by enhanced expression of NMDA receptors in the presence of a receptor reserve.
This raises a possibility that inhibition of c-Myc Max heterodimer formation by enhanc-Myc Maxssion of Mxd1 is involved in destabilizing c-Myc protein.
The neuroprotective efficacies of many other manipulations that rescue neurons from stroke damage are mediated at least in part by enhanced expression of neurotrophins, particularly BDNF.
Another example for the potential of anti-TGF-β-based strategies is scleroderma, a disease characterized by enhanced expression of TβRI and TβRII in fibroblasts leading to increased collagen I production and ECM deposition in the skin and internal organs [ 97].
Consistently, the promotion of cell cycle progression by FAK is mediated by enhanced expression of cyclin D1 and cyclin E in concert with reduced expression of CDK inhibitors p27Kip1 and p21Waf1 [ 34].
By using genetic tools in mice, we have recently shown that heterozygous deletion of Egln1, which encodes for the oxygen-sensitive prolyl hydroxylase domain (PHD) protein 2 (promotesromotes a proarteriogenic, M2-like phenotype in macrophages, characterized by enhanced expression of the macrophage mannose receptor (MRC1/CD206) and TIE2.
Considering these findings, we hypothesized that the THC-induced reduction in brain risperidone levels might be explained by enhanced expression of the ABC transporter P-gp.
In addition, tumor metastasis may be promoted by enhanced expression of prometastatic and/or downregulation of antimetastatic miRNAs.
Decrease in viability and adhesion of B16F10 cells was accompanied by enhanced expression of caspase-3.
This behavioral effect was accompanied by enhanced expression of synaptic marker proteins and increased hippocampal spine density.
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