Suppressor of Fused (SUFU) is an endogenous inhibitor of the HH-GLI1 pathway acting by either cytoplasmic sequestration of GLI1 or by inhibition of GLI1 transcription at select loci[16], [17].
Rafts may also be important in limiting signaling, either by physical sequestration of signaling components to block nonspecific interactions, or by suppressing the intrinsic activity of signaling proteins present within the rafts.
Otherwise, rafts may be important in limiting signaling, either by physical sequestration of signaling components to block nonspecific interactions or by suppressing the intrinsic activity of signaling proteins present within rafts [ 5, 6].
Maintenance of these tissue levels despite anorchid serum levels might occur either through sequestration of androgens, or by metabolism or synthesis of androgens from earlier precursors.
Mutant mitochondria would be either degraded by mitophagy (sequestration of mitochondria by autophagosomes followed by degradation in lysosomes [ 83]), or outcompeted by wild-type organelles.
That complex is believed to be responsible for the antiapoptotic function of Bcl-2, by sequestration of the BH3 motif either of the so-called BH3-only proteins such as Bim ('mode 1') or of Bax or Bak ('mode 2'mode
Interestingly, the mechanism by which Argos attenuates the EGFR pathway is by sequestration of ligand and not by direct interaction with the receptor (Klein et al., 2004; Klein et al., 2008).
Moreover, RGS5 allows for an enhanced Gα12/13-mediated Gα12/13-mediatedoactivationnof only by suppRhoAing Gαq/11 activity but alSMCsy sequestrationotf the active pronlyn.
13 14 One important component is inflammation-induced iron delocalisation, which is characterised by sequestration of iron by the monocyte macrophage system and hepatocytes, resulting in a state of pseudo-iron deficiency, a state that reverses after the inflammation has subsided.
Tumorigenesis is controlled by the sequestration of an autophagy machinery component to the cytoskeleton.
