Sentence examples for by either knocking down from inspiring English sources

However, this enrichment is significantly inhibited by either knocking down INO80 or YY1, suggesting the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region.

Together, these observations point to the fact that the DR-like state initiated by either knocking down mekk-3 or through nongenetic means may utilize similar pathways to affect longevity positively.

Therefore, we eliminated the function of FLRT1 and FLRT3 proteins by either knocking down their expression with morpholinos or by knocking down the expression of RND1, the downstream effector of FLRT proteins, as done previously [2].

This novel signal pathway offers the opportunity to engineer hMSCs to accelerate neuron differentiation by either knocking down EZH2, overexpressing Smurf2, or activating PPARγ through its agonist rosiglitazone and/or protein overexpression.

We considered experiments that test the role of eve 2 regulators by either knocking down the input TF (Stanojevic et al., 1991), or by mutating binding sites for that TF in the eve 2 enhancer (Arnosti et al., 1996).

To further support evidence for oxidative stress, we next evaluated whether a putative increased ROS production by glutamate could be rescued by either knocking down a key glycolytic enzyme, phosphoglucose isomerase (PGI), or by overexpressing glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP that we have previously shown to be efficient in neurons.

In model systems permitting genome-wide genetic interactions assays, all genes are either knocked down or knocked out and these perturbations can therefore affect the studied trait, for example fitness, by increasing it or decreasing it.

In order to confirm that all additional glial cells along the NER are perineurial glia arising from ePG2, we performed subgroup-specific inhibition of mitosis either by knocking down Cyclin A (CycA) or by ectopic expression of Retinoblastoma-family protein (Rbf).

Suppression of mitosis, either by knocking down CycA or ectopic expression of Rbf in all glia (driven by repo-Gal4), prevents the generation of additional cells along the NER.

By knocking down either LDHA or PDK1 expression in the R7 Aβ resistant cell line, we observed a significant decrease in cell viability, following exposure to 48 hr Aβ (20 µM) when compared to the control (Fig. 5 C, P<0.01).

Similarly, by knocking down either of the MPN-subunits, Rpn11 or Rpn8, we have demonstrated that base was still assembled in cells associated to 20S CP.