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Skin injury by either agent alone was quantitated by the probability of tail necrosis as a function of dose of agent.
Each effect was greater than that evoked by either agent alone, indicating enhanced efficacy for therapeutic approaches that target multiple, distinct mechanism of telomere maintenance.
This study was designed to evaluate the blood pressure lowering and cholesterol-lowering effect of a fixed-dose combination of irbesartan-atorvastatin compared with monotherapy by either agent over an 8-week treatment period.
We found that the inhibition of cell growth and induction of apoptosis was significantly greater in the combination group than that could be achieved by either agent alone.
Biomarkers of brain cell number (DNA concentration and content), cell size (protein/DNA ratio) and neuritic projections (membrane/total protein) were affected by either agent alone, with patterns consistent with neuronal and neuritic damage accompanied by reactive gliosis.
The decrease in Bcl2/Bax ratio in neurons exposed to both Tat and morphine was greater than what was induced by either agent alone.
Similar(32)
Either agent by itself induced the phosphorylation of p38 compared to control, however, the combination of NE and LPS showed the strongest activation (over 7-fold induction) of p38 in cultured KCs (Fig. 6B).
To mimic ICU conditions, animals were mechanically ventilated continuously with constant sedation induced by either a volatile anesthetic agent (isoflurane, sevoflurane or desflurane) or intravenously applied propofol.
A bloom of B. wadsworthia by use of either agent also caused a significant increase in the incidence of colitis within the Il10−/− mice [ 1].
Dual infection of pigs with PCV2 and PRRSV has consistently resulted in more severe disease than that caused by infection with either agent alone [ 29, 31, 32].
Six blended cement samples were prepared by adding either reducing agents (1% SnCl2·2H2O and FeSO4·2H2O) only or reducing agents along with agricultural waste (rice husk ash, RHA and rice tiller ash, RTA).
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