Sentence examples for by either activation of from inspiring English sources

Neurons committed to apoptosis may do so by either activation of a receptor-mediated pathway employing caspase-8 or through an alternative mitochondrial pathway involving oxidative stress.

The infection could significantly increase the number of plasmids per cell by either activation of the otherwise bacteria-specific origin of replication or by significantly increasing transfection efficiency a posteriori.

Increased cAMP can occur by either activation of AC or inhibition of PDE.

Aryloxyphosphoramidate nucleoside prodrugs are generally prepared by coupling of nucleosides with phosphorochloridate by either activation of the imidazolium intermediate with NMI or by 5′-deprotonation of the nucleoside with t-BuMgCl and subsequent substitution with the chlorophosphoramidate.

The development of accessory pathways has been demonstrated in mice by using either activation of notch signaling or inactivation of Tbx2, indicating that dysregulation of the cell signaling pathways that are essential for the development of the AV canal and the AV node may be responsible for the Wolff-Parkinson-White syndrome.

During neoplastic transformation, the replicative lifespan of human cells is extended by either the activation of a telomere maintenance mechanism (described below) or inactivation of a tumor suppressor pathway (reviewed by Reddel, 2000).

We have been unable to show either activation of ALK by heparin alone, nor any synergistic effect of heparin together with the FAM150A/B ligands.

It has been widely accepted that ICs initiate inflammatory responses in IC diseases such as arthritis or the Arthus reaction either by activation of the complement system or by the direct engagement and activation of FcγR-bearing inflammatory cells.

Growth-arresting signals can be triggered either by activation of Jun N-terminal kinases (JNKs) or by preventing both ERK and JNK activation, and sarcomeric myosin expression was induced by the ERK inhibitor U0126, but abrogated by the p38MAPK inhibitor SB203580.

Cell death is initiated either by activation of cell surface receptors upon ligand binding (extrinsic pathway) or by activation of pro-apoptotic members of the Bcl-2 family (intrinsic pathway) and both pathways are mediated via sequential activation of specific cysteinyl aspartate proteinases, caspases, to cleave specific substrates after aspartate residues.

Both Sangiorgi et al (2008) and Barker et al (2008) have used these markers to drive expression of Cre recombinase within the intestinal stem cell and thereby deregulate the Wnt pathway, either by activation of beta-catenin or inactivation of Apc.