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Although the standard drug might not decrease TG concentrations by activating lipoprotein lipase, the biflavonoid fractions from Garcinia kola could have reduced TG levels by either activating endothelium bound lipoprotein lipase which hydrolyses the triglyceride into fatty acid hence decreasing triglyceride levels as seen in a report by Sikarwar and Patil [26].
Whether the ablation of ABCA1 disables scramblase-mediated lipid movement in macrophages could be tested by either activating the scramblase with Ca2+ or by using apoptotic macrophages.
Our study reveals that disinhibiting pyramidal neurons by either activating VIP neurons or silencing SST neurons also enhances adult plasticity and allows potentiation of open-eye responses in V1, revealing an important role for at least these other major types of inhibitory neurons in cortical plasticity.
Effort is necessary to meet task demands and to compensate for a sub-optimal state of arousal and/or activation by either activating or inhibiting the arousal and activation levels.
PP2A is known to interact directly with many proteins and modify their activity by either activating or inhibiting them.
All BH3-only proteins identified so far are pro-apoptotic and function by either activating Bax and Bak or inhibiting the anti-apoptotic Bcl-2 proteins [23].
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Structural changes in critical proteins caused by gene mutations may either activate or inactivate their function.
The FRET signal obtained for experiments using the D335C mutant showed a marked contrast for mixed samples that were either activated by Ca2+/CaM and ATP or not.
Importantly, however, kinase and phosphatase activities and specificities are often modulated by subunit interactions, which can either activate or deactivate these enzymes depending on cellular conditions.
Phosphorylated ERK can either activate MITF by protein phosphorylation, or up-regulate MITF transcription through CREB phosphorylation [ 25, 26].
Cytokinesis can be rescued in these cells independent of stress fiber formation by promoting ERK signaling either by activating the mutant integrin with Mn+2 or by expressing a constitutively active Raf-1 mutant (Mathew et al., 2014; Nieves et al., 2010).
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